Publications by authors named "J Tode"
Background: Challenges in practice-oriented teaching at university clinics are increasing. A lack of resources contrasts a growing number of students. Digital lectures, seminars, and blended-learning concepts enable resource-efficient and effective teaching in ophthalmology.
View Article and Find Full Text PDFEffect of intravitreal injection of anti-interleukin (IL)-6 antibody in experimental autoimmune uveitis in mice.
J Ophthalmic Inflamm Infect
November 2024
Purpose: The aim of this study was to assess the functional and clinical impact of intravitreal administration of a neutralizing anti-IL-6 antibody in the treatment of experimental autoimmune uveitis (EAU) in mice.
Methods: EAU was induced in 17 female B10.RIII mice by administering Inter-Photoreceptor-Binding-Protein (IRBP) in complete Freund's adjuvant, followed by a boost with Pertussis toxin.
Article Synopsis
- The trabecular meshwork (TM) is essential for controlling intraocular pressure and its dysfunction is a major factor in glaucoma, a leading cause of blindness globally.
- This study compared primary human TM (hTM) cells and murine TM (mTM) cells in vitro to improve the relevance of rodent models for glaucoma research.
- Results showed similarities in cell properties and responses to stressors (like DEX and TGFB2), but also notable differences in specific protein expressions, highlighting the need for careful consideration when translating findings from mTM to human applications.
Objectives: Numerous laser and light therapies have been developed to induce regenerative processes in the choroid/retinal pigment epithelium (RPE)/photoreceptor complex, leaving the neuroretina undamaged. These therapies are applied to the macula for the treatment of various diseases, most prominently diabetic maculopathy, retinal vein occlusion, central serous chorioretinopathy, and age-related macular degeneration. However, the abundance of technologies, treatment patterns, and dosimetry protocols has made understanding these therapies and comparing different approaches increasingly complex and challenging.
View Article and Find Full Text PDFPurpose: This study aimed to assess the effectiveness of monocular and bilateral injections of Dexamethasone-21-acetate (Dex-21-Ac) into the murine fornix twice a week as a glucocorticoid-induced ocular hypertension model and investigated potential systemic side effects.
Methods: Dex-21-Ac was administered twice weekly in three groups: bilateral injections, monocular injections, and a control group receiving the vehicle solution bilateral. After 21 days, enucleated eyes were examined using immunocytochemistry (ICC), and organ histology was performed.