Publications by authors named "J Todd Kuenstner"

Article Synopsis
  • Evidence suggests a link between a bacterial infection called Mycobacterium avium ssp. paratuberculosis (MAP) in animals and Crohn's disease (CD) in humans, and there's an ongoing clinical trial focused on treating CD with antibiotics.
  • Researchers conducted a study with 199 subjects to develop MAP-based tests that help identify which CD patients also have a MAP infection, using multiple MAP antigens.
  • Results showed that combining certain MAP antigens and cytokine levels significantly improved the effectiveness of diagnosing CD compared to using any single MAP antigen alone.
View Article and Find Full Text PDF

Objectives: 1) Culture ssp. (MAP)from blood, 2) assess infection persistence, 3) determine Crohn's disease (CD) cytokine expression, 4) compare CD cytokine expression to tuberculosis, and 5) perform a meta-analysis of cytokine expression in CD.

Methods: The Temple University/Abilene Christian University (TU/ACU) study had a prospective case control design with 201 subjects including 61 CD patients and 140 non-CD controls.

View Article and Find Full Text PDF

Background: A 26-year-old male had a history of frequent bowel movements, mushy stool with mucus and loss of 25 kg body weight in 6 months was diagnosed as a case of inflammatory bowel disease (IBD). The patient did not respond to routine and standard treatment for IBD. His condition was steadily deteriorating, and he was in a very precarious state when he reported to us.

View Article and Find Full Text PDF

This article examines the policy implications of subspecies (MAP) as a zoonotic pathogen and the public health risks posed by the presence of MAP in food, particularly milk products. Viable MAP has been cultured from commercially pasteurized milk in the US. Dairy pasteurization standards and regulations are examined in light of this finding.

View Article and Find Full Text PDF

subspecies (MAP) has long been suspected to be involved in the etiology of Crohn's disease (CD). An obligate intracellular pathogen, MAP persists and influences host macrophages. The primary goals of this study were to test new rapid culture methods for MAP in human subjects and to assess the degree of viable culturable MAP bacteremia in CD patients compared to controls.

View Article and Find Full Text PDF