Publications by authors named "J Tjoe"
Background: For patients with ductal carcinoma in situ (DCIS) undergoing breast conservation surgery (BCS), guidelines advise a margin width of at least 2 mm, with studies demonstrating decreased recurrence risk compared to narrower margins. However, limited data exist establishing if this margin is appropriate in mastectomies, and specifically for nipple-sparing mastectomy (NSM). Consequently, we evaluated the margins of DCIS patients undergoing NSM and resulting oncologic outcomes.
View Article and Find Full Text PDFWe report the 20-year rate of ipsilateral breast event (IBE) for patients with ductal carcinoma in situ (DCIS) treated with lumpectomy without radiation on a non-randomized prospective clinical trial. Patients were enrolled in cohort 1: low- or intermediate-grade DCIS, size ≤ 2.5 cm (n = 561); or cohort 2: high-grade DCIS, size ≤ 1 cm (n = 104).
View Article and Find Full Text PDFArticle Synopsis
- The STEEP 2.0 criteria, updated in 2021, established standardized definitions for adjuvant breast cancer end points and emphasized the importance of defining neoadjuvant clinical trial end points separately.
- A specialized working group, NeoSTEEP, focused on neoadjuvant systemic therapy end points, considering various factors like cancer subtypes, imaging, and FDA regulations.
- The group recommended defining pathologic complete response (pCR) as no residual invasive cancer present and suggested additional methodologies for evaluating treatment efficacy, including unique end points for hormone receptor-positive cases.
The American Society of Breast Surgeons recommends sending separate nipple margins (NMs) when performing nipple-sparing mastectomies (NSMs). However, the definition of a positive NM is vague. We evaluated NM management and outcomes in breast cancer patients undergoing NSM from 2010 to 2021 at our community-based hospital system through a retrospective review and descriptive analysis.
View Article and Find Full Text PDF