Accelerating Clean Energy Transitions to Safeguard Human Health and Survival.

The year 2023 was the warmest year in the 174-year global instrumental record. The year was also marked by a series of climate-related extreme events, including heat waves, storms, and wildfires that caused widespread economic and health impacts. The 28th Conference of the Parties of the United Nations Framework Convention on Climate Change called for transitioning away from fossil fuels and accelerating action in this critical decade.

Sex differences in the association of Alzheimer's disease biomarkers and cognition in a multicenter memory clinic study.

Background: This study investigated sex differences in the associations between Alzheimer's disease (AD) biomarkers, cognitive performance, and decline in memory clinic settings.

Methods: 249 participants (females/males:123/126), who underwent tau-PET, amyloid-PET, structural MRI, and plasma glial fibrillary acidic protein (GFAP) measurement were included from Geneva and Lausanne Memory Clinics. Mann-Whitney U tests investigated sex differences in clinical and biomarker data.

Discordance between Y-PET/CT(MR)-estimated activity and dose calibrator measured administered activity: an international study in SIRT patients treated with resin and glass microspheres.

Purpose: Therapeutic administration of Y-loaded microspheres is routinely used for primary and secondary liver tumours. For activity-based therapeutic prescription the activity must be within 10% of the intended activity. Previous studies reported significant discrepancies between manufacturer-declared vial activities and both experimental and Monte-Carlo assessments, greater than 10%, for resin/glass Y-microspheres.

The value of AI for assessing longitudinal brain metastases treatment response.

Background: Effective follow-up of brain metastasis (BM) patients post-treatment is crucial for adapting therapies and detecting new lesions. Current guidelines (Response Assessment in Neuro-Oncology-BM) have limitations, such as patient-level assessments and arbitrary lesion selection, which may not reflect outcomes in high tumor burden cases. Accurate, reproducible, and automated response assessments can improve follow-up decisions, including (1) optimizing re-treatment timing to avoid treating responding lesions or delaying treatment of progressive ones, and (2) enhancing precision in evaluating responses during clinical trials.

Cancer-targeted pro-theranostic bi-metallic organo-coordination nanoparticles.

Cancer remains a leading cause of mortality, with aggressive, treatment-resistant tumors posing significant challenges. Current combination therapies and imaging approaches often fail due to disparate pharmacokinetics and difficulties correlating drug delivery with therapeutic response. In this study, we developed radionuclide-activatable theranostic nanoparticles (NPs) comprising folate receptor-targeted bimetallic organo-nanoparticles (Gd-Ti-FA-TA NPs).