Publications by authors named "J Timms"
biogroup is a human-adapted pathogen and the causative agent of Brazilian purpuric fever (BPF), an invasive disease with high mortality, that sporadically manifests in children previously suffering conjunctivitis. Phase variation is a rapid and reversible switching of gene expression found in many bacterial species, and typically associated with outer-membrane proteins. Phase variation of cytoplasmic DNA methyltransferases has been shown to play important roles in bacterial gene regulation and can act as epigenetic switches, regulating the expression of multiple genes as part of systems called phasevarions (phase-variable regulons).
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- The COVID-19 pandemic has stressed global healthcare systems, highlighting the need for better methods to allocate treatment and resources in intensive care for critically ill patients.
- Current risk assessment tools like SOFA and APACHE II have shown limited effectiveness in predicting outcomes for severe COVID-19 patients, necessitating additional monitoring tools, especially for those undergoing experimental therapies.
- A study analyzing plasma proteins from critically ill COVID-19 patients identified 14 proteins that could predict survival more accurately than existing methods, achieving high classification accuracy, especially in relation to coagulation and complement processes.
Background: Earlier detection of pancreatic ductal adenocarcinoma (PDAC) is key to improving patient outcomes, as it is mostly detected at advanced stages which are associated with poor survival. Developing non-invasive blood tests for early detection would be an important breakthrough.
Methods: The primary objective of the work presented here is to use a dataset that is prospectively collected, to quantify a set of cancer-associated proteins and construct multi-marker models with the capacity to predict PDAC years before diagnosis.