Induction of apoptosis by a Newcastle disease virus vaccine (MTH-68/H) in PC12 rat phaeochromocytoma cells.

The attenuated Newcastle Disease Virus (NDV) vaccine MTH-68/H has been found to cause regression of various tumors including certain types of human neoplasms (See Table 1 and References 86-88). The mechanism of its oncolytic action is poorly understood, but it appears to affect specific signaling pathways in the target cell. We studied the cellular effects of NDV employing PC12 rat phaeochromocytoma cells, a widely used model system to analyze differentiation, proliferation and apoptosis.

Local anesthetics inhibit receptors coupled to phosphoinositide signaling in Xenopus oocytes.

Effects and the mechanism of action of quaternary amine local anesthetics on ligand- and voltage-activated ion currents were studied using voltage-clamped ovarian follicles and oocytes from Xenopus laevis. The fast inward and slow outward currents in response to acetylcholine were unaltered by procaine, whereas the oscillatory and smooth inward chloride currents (ICl) were abolished. Potassium currents (IK) elicited by norepinephrine and oscillatory ICl elicited by lysophosphatidic acid were blocked.

Activation heat in various cross-striated muscles of Rana esculenta: microcalorimetric measurements.

Activation heat (AH) is an important component in energy balance of muscle contraction. It represents energy dissipation of biochemical processes enabling muscle in rest to perform contraction. According to our measurements on intact muscles, AH is 20% of initial heat production in twitch, and 10% in tetanus.