Publications by authors named "J Tiernan"
Purpose: Anorectal and urogenital dysfunctions are common after rectal surgery and have a significant impact on quality of life. Intraoperative pelvic autonomic nerve monitoring (pIONM) has been proposed as a tool to identify patients at risk of these functional sequelae. This systematic review aims to evaluate the diagnostic accuracy of pIONM in detecting anorectal and urogenital dysfunction following rectal surgery.
View Article and Find Full Text PDFAim: Recovery after surgery for colorectal cancer is a complex process, involving numerous physiological, emotional, social and economic challenges. Good information is a key factor for enabling patients to recover well, but there is a paucity of evidence to guide how this should be done. A new information intervention (Recover Together) comprising a booklet, an online video and an inpatient goal board has been developed.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to understand how multidisciplinary teams (MDTs) in Great Britain and Ireland provide clinical services for patients with locally advanced and recurrent colorectal cancer, to support future service improvements.
- A survey with 12 questions was distributed to all colorectal cancer MDTs in GB&I, with a high response rate of 93.5%, encompassing 175 participating teams.
- Results showed significant variation in available services, including surgical options and specialized care, with only a minority of hospitals offering certain advanced surgical techniques and dedicated support for patients.
Article Synopsis
- The study aimed to create global benchmark outcomes for pelvic exenteration (PE) in patients with locally advanced primary rectal cancer (LARC) and recurrent rectal cancer (LRRC), drawn from data at specialized centers.
- Researchers conducted a retrospective analysis of 763 patients across 16 experienced centers from 2018 to 2023, focusing on a subgroup of 544 lower-risk patients to establish ten key outcome benchmarks.
- The findings set specific targets for major complication rates, mortality rates, and R0 resection rates that can guide surgical quality assessments and improvements in PE procedures worldwide.
Article Synopsis
- - Theranostic nanoparticles, designed for both imaging and therapy, target colorectal cancer by focusing on the overexpressed carcinoembryonic antigen (CEA), while using synthetic proteins called Affimers for enhanced targeting efficiency.
- - Silica nanoparticles were created and loaded with the photosensitiser Foslip, allowing for effective fluorescence imaging and photodynamic therapy (PDT) when functionalized with anti-CEA Affimers.
- - In experiments with colorectal cancer cell lines and mouse models, these targeted nanoparticles showed significant fluorescence and induced substantial cell death, leading to a notable 4-fold reduction in tumor volume, indicating their potential for effective cancer treatment.