Publications by authors named "J Thomason"
Our study investigated the therapeutic potential of OKN-007 in the SOD1 G93A mouse model of amyotrophic lateral sclerosis (ALS). The impact of OKN-007, known for its antioxidant, anti-inflammatory, and neuroprotective properties, was tested at two doses (150 mg/kg and 300 mg/kg) at onset and late-stage disease. Results demonstrated a significant delay in disease progression at both doses, with treated mice showing a slower advance to early disease stages compared to untreated controls.
View Article and Find Full Text PDFObjective: Giant cell arteritis (GCA) is the most common vasculitis and can result in blindness due to anterior ischemic optic neuropathy (AION). Little is known about which patients with GCA are at higher risk of AION. We did a retrospective chart review to compare demographics, past medical history, labs and imaging of GCA patients with and without AION.
View Article and Find Full Text PDFThis case series describes spontaneous resolution of systolic anterior motion of the mitral valve, cessation of a dynamic left ventricular outflow tract obstruction, and reverse cardiac remodeling in 4 young cats. Following initial presentation with or without congestive heart failure, subsequent rechecks documented resolution of systolic anterior motion of the mitral valve and normalization of left heart dimensions. Those cats originally presented with congestive heart failure were successfully weaned off diuretic medications.
View Article and Find Full Text PDFArticle Synopsis
- A study looked at how often dogs have problems after getting blood transfusions, focusing on 858 dogs that received 1,542 transfusions from March to November 2022.
- Out of the dogs, 8.9% experienced acute reactions when they got packed red blood cells, and 4.5% had reactions after receiving plasma products.
- The study found that older stored blood and higher doses were linked to more reactions, so vets should pay attention to these factors when treating dogs.
Article Synopsis
- Management of immune thrombocytopenia (ITP) in dogs and cats lacks established evidence-based guidelines, leaving treatment decisions largely to clinician discretion.
- The first-line treatment involves immunosuppressive glucocorticoids, with additional therapies such as azathioprine and vincristine used in more severe cases; however, optimal regimens are still unclear.
- A consensus process involving a structured literature review and expert opinions led to the creation of guidelines highlighting the need for further research in ITP treatment options.