Publications by authors named "J Theiler"
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant BA.2.86 has over 30 mutations in spike compared with BA.
View Article and Find Full Text PDFUnlabelled: A series of SARS-CoV-2 variants emerged during the pandemic under selection for neutralization resistance. Convalescent and vaccinated sera show consistently different cross-neutralization profiles depending on infecting or vaccine variants. To understand the basis of this heterogeneity, we modeled serum cross-neutralization titers for 165 sera after infection or vaccination with historically prominent lineages tested against 18 variant pseudoviruses.
View Article and Find Full Text PDFArticle Synopsis
- Since late 2020, new SARS-CoV-2 variants have frequently appeared, showing differences that may help them evade immunity from past infections.
- The Early Detection group within the NIH's SARS-CoV-2 program utilizes bioinformatics to track these variants' emergence, spread, and traits, highlighting important ones for further study.
- Since April 2021, this group has successfully prioritized variants each month, assisting NIH researchers by providing timely data on SARS-CoV-2 evolution for guiding experiments.
Background: Throughout the COVID-19 pandemic, the SARS-CoV-2 virus has continued to evolve, with new variants outcompeting existing variants and often leading to different dynamics of disease spread.
Methods: In this paper, we performed a retrospective analysis using longitudinal sequencing data to characterize differences in the speed, calendar timing, and magnitude of 16 SARS-CoV-2 variant waves/transitions for 230 countries and sub-country regions, between October 2020 and January 2023. We then clustered geographic locations in terms of their variant behavior across several Omicron variants, allowing us to identify groups of locations exhibiting similar variant transitions.