Publications by authors named "J Thapa"

Background: Maple Syrup Urine Disease (MSUD) is a rare inherited disorder of metabolism, which manifests early in life in classical forms. Recurrent illness and exertion aggravate neurotoxicity. This case highlights MSUD diagnosed in association with COVID-19 complications from Nepal.

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Article Synopsis
  • COVID-19 patients are at a higher risk for fungal infections, prompting a study to identify fungal pathogens in both COVID positive and negative patients, as well as assess their antifungal resistance and biofilm formation abilities.
  • The study found a 6.70% prevalence of fungal pathogens in COVID-positive cases and 22.77% in negative cases, with Candida albicans being the most common pathogen identified.
  • Results indicated that most Candida species were susceptible to miconazole but resistant to ketoconazole, highlighting the need for increased awareness and antifungal susceptibility testing in clinical settings.
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Background: The inappropriate use of antibiotics in hospitals contributes to the development and spread of antimicrobial resistance (AMR). This study evaluated the prevalence of antibiotic use and adherence to the World Health Organization (WHO) Access, Watch and Reserve (AWaRe) classification of antibiotics across 16 hospitals in Zambia.

Methods: A descriptive, cross-sectional study employing the WHO Point Prevalence Survey (PPS) methodology and WHO AWaRe classification of antibiotics was conducted among inpatients across 16 hospitals in December 2023, Zambia.

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Background: Antimicrobial stewardship (AMS) programs are critical in combating antimicrobial resistance (AMR). In Zambia, there is little information regarding the capacity of hospitals to establish and implement AMS programs. The objective of this study was to conduct a baseline assessment of WHO core elements for an AMS program implementation in eight hospitals in Zambia.

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