Publications by authors named "J Thaden"
Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism in glucose substrate supply during the acute phase of sepsis. In a translational porcine model of sepsis, we explored the across organ net fluxes of gluconeogenic substrates.
View Article and Find Full Text PDFBackground: Mitral transcatheter edge-to-edge repair (TEER) is a minimally invasive therapy for severe mitral regurgitation (MR) in patients with high surgical risk. TEER results in a tissue bridge that decreases mitral valve area, potentially leading to elevated mean gradient. The clinical impact of elevated gradient on outcomes is unclear.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the prognostic value of right ventricle (RV) function and its coupling to pulmonary artery pressure in patients with tricuspid regurgitation (TR) to improve risk evaluation beyond an established clinical score.
- Researchers analyzed data from 417 patients with moderate TR and developed a new risk score by integrating RV function measures, finding significant correlations between these parameters and patient mortality during a median follow-up of nearly 4 years.
- Results showed that many patients initially categorized as low- or intermediate-risk were reclassified to higher risk when RV function metrics were included, indicating that incorporating these echocardiographic measures enhances mortality predictions in TR patients.