Effect of acrylate chemistry on human health.

Objectives: The prospective cohort study of 1992-1999 describes the effect of occupational exposure to chemical substances in the production of acrylic acid, acrylic acid esters and acrylate dispersions at the various workplaces of one chemical plant.

Methods: Exposure to selected chemicals (acrylonitrile, n-butanol, butyl acrylate, ethyl acrylate, methyl acrylate, methyl methacrylate, toluene, and styrene) was determined by personal passive dosimetry (GC/MS method). The annual examinations included general health, by guided interview, a general medical examination, hematological and biochemical examinations, examination of the parameters of serum immunity and selected tumor markers, and spirometry.

A rapid and simple method for the analysis of 1-hydroxypyrene glucuronide: a potential biomarker for polycyclic aromatic hydrocarbon exposure.

The present study describes a simple method of analyzing metabolites of pyrene in urine. This method is capable of detecting the glucuronic acid and sulfate conjugates of pyrene as well as free 1-hydroxypyrene in a single analysis. In comparison to other analytical methods for detecting pyrene metabolites, this new method does not require an overnight enzymatic hydrolysis step and is much more rapid method of analysis.