Publications by authors named "J Teissere"

We report on an experimental study of heterogeneous slip instabilities generated during stick-slip motions at a contact interface between a smooth rubber substrate and a patterned glass lens. Using a sol-gel process, the glass lens is patterned with a lattice of parallel ridges (wavelength, 1.6 μm, amplitude 0.

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The imidazopyridine zolpidem (Ambien) is one of the most commonly prescribed sleep aids in the United States (Rush, 1998). Similar to classic benzodiazepines (BZDs), zolpidem binds at the extracellular N-terminal alpha/gamma subunit interface of the GABA-A receptor (GABAR). However, zolpidem differs significantly from classic BZDs in chemical structure and neuropharmacological properties.

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Article Synopsis
  • GABA, a neurotransmitter, works as an inhibitory signal in the brain through GABA(A) and GABA(B) receptors, each functioning differently in how they influence cellular activity.
  • The study shows that GABA(B)R1 can pair with a subunit from GABA(A) (gamma2S), which helps the GABA(B)R1 reach the cell surface more effectively, even without its usual partner, GABA(B)R2.
  • Although the GABA(B)R1/gamma2S complex alone does not trigger any observable function, when gamma2S is present, it enhances the GABA(B) receptor's internalization process when activated, indicating a complex interplay between these receptor types that
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Several structural subclasses of ligands bind to the benzodiazepine (BZD) binding site of the GABA(A) receptor. Previous studies from this laboratory have suggested that imidazobenzodiazepines (i-BZDs, e.g.

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Benzodiazepines (BZDs) exert their effects in the CNS by binding to a modulatory site on GABA(A) receptors. Individual amino acids have been implicated in BZD recognition and modulation of the GABA(A) receptor, but the secondary structure of the amino acids contributing to the BZD binding site has not been elucidated. In this report we used the substituted cysteine accessibility method to understand the structural dynamics of a region of the GABA(A) receptor implicated in BZD binding, gamma(2)Y72-gamma(2)Y83.

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