Publications by authors named "J Teillon"

Tissue clearing enables deep imaging of long biological structures using light microscopy approaches. Protocols such as iDISCO are not currently available for human skin. Here, we present Skin-iDISCO, a tissue-clearing and labeling protocol for morphometric analysis of human cutaneous vasculature.

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Article Synopsis
  • The hypothalamus has lots of different neurons that control behavior and metabolism, and these neurons can change over time.
  • Researchers found special 'Ghost' neurons, which don't act like regular ones and were previously unnoticed by other methods.
  • The number of Ghost neurons increases in mice that gain weight from unhealthy diets, but they can change back when the mice lose weight, showing that neurons can adapt based on diet.
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Plants are able to naturally graft or inosculate their trunks, branches and roots together, this mechanism is used by humans to graft together different genotypes for a range of purposes. Grafts are considered successful if functional vascular connections between the two genotypes occur. Various techniques can evaluate xylem connections across the graft interface.

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Dysregulated autophagy is associated with cardiovascular and metabolic diseases, where impaired flow-mediated endothelial cell responses promote cardiovascular risk. The mechanism by which the autophagy machinery regulates endothelial functions is complex. We applied multi-omics approaches and in vitro and in vivo functional assays to decipher the diverse roles of autophagy in endothelial cells.

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