Publications by authors named "J Tapia"
Article Synopsis
- * In the KARISMA trial, 824 women were analyzed, finding that a decrease in MBD was linked to endoxifen levels of 2-3 ng/mL, particularly in those taking 5-10 mg doses of tamoxifen.
- * The research suggests a potential range of effective endoxifen levels for improving MBD in premenopausal women, but emphasizes the need for studies using established clinical outcomes for confirmation.
Driving is a complex task necessitating an intricate interplay of sensory, motor, and cognitive abilities. Extensive research has underscored the role of neurocognitive functions, including attention, memory, executive functions, and visuospatial skills, in driving safety and performance. Despite evidence suggesting cognitive training's potential in enhancing driving abilities, comprehensive cognitive training's impact on driving performance in young adult drivers remains unexplored.
View Article and Find Full Text PDFBackground: Lung cancer constitutes the leading cause of cancer mortality. High levels of endothelin-1 (ET-1), its cognate receptor ETR and its activating enzyme, the endothelin-converting enzyme-1 (ECE-1), have been reported in several cancer types, including lung cancer. ECE-1 comprises four isoforms, which only differ in their cytoplasmic N-terminus.
View Article and Find Full Text PDFExopolysaccharides (EPSs), a constitutive part of bacterial biofilm, act as a protecting sheath to the extremophilic bacteria and are of high industrial value. In this study, we elucidate a new EPS produced by thermotolerant (growth from 34-44 °C) strain Pseudomonas alcaligenes Med1 from Medano hot spring (39.1 °C surface temperature, pH 7.
View Article and Find Full Text PDFArticle Synopsis
- Previous research has shown that both (R,S)-ketamine and its metabolite (2S,6S)-HNK can reduce learned fear in mice when administered before experiencing stress.
- A study involved injecting mice with these compounds and then assessing neural activity related to fear after a fear conditioning task.
- The findings suggest that both drugs affect different neural pathways associated with fear and could lead to new methods for treating fear-related disorders by targeting specific brain areas.