Publications by authors named "J Tanyi Mbafor"
Two new compounds, an isoquinoline () and caloneuramide (), a ceramide were isolated from the stem bark of together with seven known compounds namely aurantiamide acetate (), acetylaleuritolic acid (), 3-hydroxylaleuritolic acid 2-p-hydroxybenzoate (), mixture of stigmasterol () and -sitosterol (), mixture of 7-oxo-stigmasterol () and 7-oxo--sitosterol (). Their structures were determined based on data from literature and spectroscopic methods. Derivatization reactions on the isoquinoline led to two new compounds, the methylated () and acetylated () derivatives.
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- A new alkaloid, 8,9-dimethoxy-5-phenanthridin-6-one, along with two flavonoids, was isolated for the first time from a natural source.
- The compounds were characterized using advanced NMR spectroscopy and mass spectrometry to determine their structures.
- Some fractions showed strong antifungal activity against certain yeast strains, suggesting that the source may have potential for developing antifungal drugs.
Article Synopsis
- - Propolis from Cameroon was studied, leading to the discovery of a new isoflavonol and other compounds, some of which had not been previously identified from propolis.
- - The compounds were tested for their effects on oxidative stress, with one (2-hydroxy-8-prenylbiochanin A) showing significant inhibition of nitric oxide production and others demonstrating higher reactive oxygen species inhibition than ibuprofen.
- - Cytotoxicity and antifungal activities were also assessed, revealing moderate cytotoxicity for some extracts and lower antifungal efficacy compared to standard treatments like fluconazole.
Inflammatory diseases are a real public health problem worldwide. Many synthetic drugs used in the treatment of inflammatory diseases such as steroidal anti-inflammatory drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressive drugs have harmful side effects. However, there are natural products like propolis, which is traditionally used in the treatment of pain.
View Article and Find Full Text PDFChemical investigation of Baker resulted in the isolation of a new depsidone, cordidepsine (), along with twelve known compounds including cyclooctasulfur (), lup-20(29)-en-3-triacontanoate (), 1-(26-hydroxyhexacosanoyl)glycerol (), glyceryl-1-hexacosanoate () betulinic acid (), lupenone (), -amyrone (), lupeol (), -amyrin (), allantoin (), 2'-(4-hydroxyphenyl)ethylpropanoate () and stigmasterol glycoside (). Hemi-synthetic reactions were carried out on two isolated compounds ( and ) to afford two new derivatives, that is, cordicerol A () and cordicerol B (), respectively. The chemical structures of all the compounds were established based on analysis and interpretation of spectroscopic data such as electron ionization mass spectrometry (EI-MS), high resolution electrospray ionization mass spectrometry (HR-ESI-MS), fast atom bombardment mass spectrometry (FAB-MS), one dimension and two dimension nuclear magnetic resonance (1D and 2D-NMR) spectral data as well as X-ray crystallography (XRC).
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