Cross-species drug metabolism and impact of metabolic stability testing under anaerobic condition on predicting pharmacokinetics of keto-enol containing compound in humans.

After oral administration of [C]-S-1360 in rats and dogs, [C]-S-1360 was absorbed rapidly and the bioavailability was 93.7% in rats and 75.1% in dogs.

Optical frequency domain angle measurement in a femtosecond laser autocollimator.

A mode-locked laser autocollimator, in which a group of first-order diffracted beams from a grating reflector are detected by an autocollimation unit, has an expanded angle measurement range compared with a conventional autocollimator using a single-wavelength laser source. In this paper, a new optical frequency domain angle measurement method is proposed to increase the visibility of output signal of the mode-locked femtosecond laser autocollimator, which is limited by the overlap of the focused diffracted light spots. The output visibility of a prototype femtosecond laser autocollimator has been increased by the proposed method to approximately 100% over a large range of 21600 arc-seconds.

Design, development, and evaluation of a novel microneedle array-based continuous glucose monitor.

The development of accurate, minimally invasive continuous glucose monitoring (CGM) devices has been the subject of much work by several groups, as it is believed that a less invasive and more user-friendly device will result in greater adoption of CGM by persons with insulin-dependent diabetes. This article presents the results of preliminary clinical studies in subjects with diabetes of a novel prototype microneedle-based continuous glucose monitor. In this device, an array of tiny hollow microneedles is applied into the epidermis from where glucose in interstitial fluid (ISF) is transported via passive diffusion to an amperometric glucose sensor external to the body.

Polysaccharide-hair cationic polypeptide nanogels: self-assembly and enzymatic polymerization of amylose primer-modified cholesteryl poly(L-lysine).

In this study, we prepared a new associating polymer, ChMaPLL, by the substitution of the poly(L-lysine) moiety with oligosaccharide amylose primer and cholesterol. ChMaPLL formed positively charged polypeptide nanogels (~50 nm) via self-assembly in water. The nanogels showed a secondary structural transition to an α-helix structure induced by poly(L-lysine) in response to an increase in pH.

Effect of formulation factors on electroosmotic glucose transport through human skin in vivo.

Glucose transport through human skin can be facilitated by electroosmotic flow that results from the application of an electric current across the skin (iontophoresis). A series of studies on human volunteers examined how formulation factors (buffer type, pH, ionic strength, and buffer concentration) affect the amount of glucose extracted from interstitial fluid through the skin. Sampling cells were placed on subjects' forearms and a current of 0.