Publications by authors named "J Takeshita"
We previously reported that the area under the curve of log-transformed cytomegalovirus antigenemia (CMV-AUC) until 100 days after allogeneic hematopoietic cell transplantation (allo-HCT) was associated with an increased risk of non-relapse mortality. We applied a risk-adapted letermovir (LTV) prophylaxis strategy guided by a risk score that predicts a higher CMV-AUC. First, we retrospectively analyzed 278 allo-HCT recipients between 2007 and 2017 (Period 1).
View Article and Find Full Text PDFThe demand for alternatives to animal testing has increased, but there has been no significant progress in developing alternatives for repeated-dose toxicity tests despite their importance in chemical risk assessment. A comprehensive analysis of existing toxicity studies is the first step toward understanding toxicity and developing alternatives. However, such an analysis has yet to be performed for industrial chemicals.
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- - Organic polymers like cross-linked polyacrylic acid (CL-PAA), widely used in various products, have been linked to severe lung diseases, prompting research into the effects of inhalation exposure rather than just instillation.
- - The study involved two exposure durations (5 days and 13 weeks) with male F344 rats, revealing that both short- and long-term exposure to CL-PAA caused significant inflammation, increased neutrophil activity, and lung fibrosis, especially at higher concentrations.
- - Administration of the antioxidant N-acetylcysteine (NAC) reduced the adverse effects of CL-PAA, decreasing inflammation markers and improving overall lung tissue health, indicating it may offer a protective benefit against oxidative stress-induced
Article Synopsis
- - The study aimed to assess whether the type of endotracheal tube (cuffed vs. uncuffed) impacts the risk of respiratory adverse events (RAEs) in young patients with airway hypersensitivity.
- - Researchers analyzed data from pediatric patients under general anesthesia between January 2021 and December 2022, comparing RAE occurrences following extubation in those with cuffed versus uncuffed tubes.
- - Findings indicated that there were no significant differences in the rates of RAEs or the need for respiratory interventions between the two groups, suggesting cuffed tubes don't increase respiratory risks in this patient population.