Publications by authors named "J Tai"
Biofilms are ubiquitous surface-associated bacterial communities embedded in an extracellular matrix. It is commonly assumed that biofilm cells are glued together by the matrix; however, how the specific biochemistry of matrix components affects the cell-matrix interactions and how these interactions vary during biofilm growth remain unclear. Here, we investigate cell-matrix interactions in Vibrio cholerae, the causative agent of cholera.
View Article and Find Full Text PDFAllergic rhinitis (AR) is a widespread health issue with a rising global prevalence, and sublingual immunotherapy (SLIT) has shown efficacy in AR treatment. We examined specific immunoglobulin G4 (sIgG4) expression in AR and its role in evaluating SLIT efficacy and predicting patient prognosis. We compared total nasal symptom score (TNSS), total medication score (TMS), visual analogue scale (VAS) score, inflammatory cytokines, and immune function markers in AR patients before and after SLIT.
View Article and Find Full Text PDFArticle Synopsis
- Colon cancer, traditionally understood through direct spread and standard metastasis methods, is seeing increased focus on the role of perineural invasion (PNI) in its progression, though research on PNI mechanisms and biomarkers remains limited.
- The study used bioinformatics to identify genes associated with PNI in colon cancer, specifically analyzing AGRN, which was linked to tumor growth and invasion through gene enrichment analysis.
- Results showed that AGRN is overexpressed in colon cancer with PNI and correlates with poorer patient outcomes, suggesting it plays a critical role in PNI development and progression by enhancing both tumor and neural cell activity.*
Article Synopsis
- Biofilms are communities of bacteria that attach to surfaces and are held together by a matrix, but how this matrix interacts with the cells is not fully understood.
- The study focuses on *Vibrio cholerae*, the bacteria responsible for cholera, and reveals that the main matrix component, Vibrio polysaccharide (VPS), does not attract the cells, but a protein called Bap1 helps link the cells together.
- As biofilms age, changes in VPS levels and a process called surface trimming lead to a shift in cell-matrix interactions from attractive to repulsive, promoting cell dispersal and potentially enriching our understanding of biofilm growth dynamics in other microorganisms.
Background: This study aimed to evaluate the pharmacokinetic (PK), pharmacodynamic (PD) similarity, comparable safety, and immunogenicity between LY06006, European Union-sourced denosumab (EU-DEN), and United States-sourced denosumab (US-DEN).
Research Design And Methods: In this double-blind, parallel-group, and single-dose study, 300 healthy male subjects were randomized 1:1:1 to receive a 60 mg dose of either LY06006, EU-DEN, or US-DEN subcutaneously. This study lasted for 253 days.