Searching for responders to multidomain dementia prevention in late life: A pooled analysis of individual participant data from the MAPT and preDIVA trials.

Introduction: It is unknown in which, if any, subgroups of older adults multidomain interventions are effective at reducing long-term dementia incidence.

Methods: We pooled up to 12 years of follow-up data from 5205 participants aged > 70 from the Multidomain Alzheimer Preventive Trial (MAPT) and Prevention of Dementia by Intensive Vascular Care (preDIVA) studies. The primary outcome was incident all-cause dementia.

Chronic Cerebral Deterioration - A Comprehensive View of Old-Age Cerebral Deterioration.

The current one-dimensional view of pathological brain changes in older persons leading to cognitive complaints, mild cognitive impairment, and ultimately dementia is incomplete. It neglects the earliest, non-cognitive, and multifaceted symptoms of gradually accumulating cerebral damage. Subtle personality changes, balance problems, muscle wasting, weight loss, changing sleep patterns and declining blood pressure and cholesterol, precede memory problems and cognitive impairment.

Corrigendum to "Antihypertensive medication classes and risk of incident dementia in primary care patients: a longitudinal cohort study in the Netherlands" [The Lancet Regional Health-Europe, Volume 42, July 2024, 100927].

[This corrects the article DOI: 10.1016/j.lanepe.