Publications by authors named "J T WORTHAM"
During July 7-11, 2023, CDC received reports of two patients in different states with a tuberculosis (TB) diagnosis following spinal surgical procedures that used bone allografts containing live cells from the same deceased donor. An outbreak associated with a similar product manufactured by the same tissue establishment (i.e.
View Article and Find Full Text PDFObjective: Death from tuberculosis or HIV among people from racial and ethnic minority groups who are aged <65 years is a public health concern. We describe age-adjusted, absolute, and relative death rates from HIV or tuberculosis from 2011 through 2020 by sex, race, and ethnicity among US residents.
Methods: We used mortality data from the Centers for Disease Control and Prevention online data system on deaths from multiple causes from 2011 through 2020 to calculate age-adjusted death rates and absolute and relative disparities in rates of death by sex, race, and ethnicity.
Trends in tuberculosis clinicians' adoption of short-course regimens for latent tuberculosis infection.
J Clin Tuberc Other Mycobact Dis
December 2023
Article Synopsis
- The study examines the prescribing patterns for latent tuberculosis infection treatments in the U.S. since updated CDC guidelines introduced shorter regimens in 2011.
- Researchers analyzed data from over 20,000 high-risk individuals and found that a significant majority were treated with the more efficient 4-month rifampin regimen.
- There has been a notable increase in the adoption of these shorter treatment regimens, rising from 55% in 2013 to 81% by late 2016, indicating a shift in practice.
Article Synopsis
- Clinical trials during infectious disease outbreaks like COVID-19 often face challenges in quickly enrolling a representative study population, which can impact treatment identification against morbidity and mortality.
- The study assessed participant demographics in the Adaptive COVID-19 Treatment Trial (ACTT) by comparing enrolled data against COVID-19 surveillance networks and US Census information, focusing on sex, race, ethnicity, and age.
- Results showed that while ACTT's demographic makeup somewhat aligned with COVID-NET data, it highlighted discrepancies such as a lower proportion of females enrolled compared to reference datasets, indicating that using surveillance data is more relevant than census data in understanding the affected population.