Real-world use of tirzepatide among individuals without evidence of type 2 diabetes: Results from the Veradigm® database.

Aims: To understand real-world tirzepatide use among individuals without type 2 diabetes (T2D) diagnoses in a US electronic health record (EHR) database.

Materials And Methods: This retrospective, descriptive, cohort study used Veradigm's® Network EHR database linked with administrative claims. Adults (≥18 years) included had ≥1 tirzepatide prescription (index period: 13 May 2022-31 August 2023); continuous medical and pharmacy enrolment for ≥12 months pre-index; and no T2D diagnosis or baseline T2D medications except metformin (overall cohort).

Assessing the readiness and feasibility to implement a model of care for spine disorders and related disability in Cross Lake, an Indigenous community in northern Manitoba, Canada: a research protocol.

Background: Since the 1990s, spine disorders have remained the leading cause of global disability, disproportionately affecting economically marginalized individuals, rural populations, women, and older people. Back pain related disability is projected to increase the most in remote regions where lifestyle and work are increasingly sedentary, yet resources and access to comprehensive healthcare is generally limited. To help tackle this worldwide health problem, World Spine Care Canada, and the Global Spine Care Initiative (GSCI) launched a four-phase project aiming to address the profound gap between evidence-based spine care and routine care delivered to people with spine symptoms or concerns in communities that are medically underserved.

More empathy for others, more hurt for oneself? Empathy for pain is related to poor mental health and negative emotion regulation.

Background: Empathy for pain refers to a simulation of pain experiences evoked when seeing others in pain. Empathy for pain (vicarious pain) responders make up 27% of the healthy population, and are divided into two subsets: Sensory/Localized responders who feel localized physical pain and Affective/General responders who experience diffuse emotional pain. Empathy for pain is linked to pro-social behavior but can increase mental health symptoms.

Exploring the relationship between experience of vaccine adverse events and vaccine hesitancy: A scoping review.

Fear of side effects is the main motive for vaccine refusal. However, before the COVID-19 pandemic, little attention had been paid to the actual experience of adverse events and its relationship with vaccine hesitancy. This scoping review aimed to analyze the impact of VH on EAE and vice versa.

Web-Based Application for Reducing Methamphetamine Use Among Aboriginal and Torres Strait Islander People: Randomized Waitlist Controlled Trial.

Background: Digital interventions can help to overcome barriers to care, including stigma, geographical distance, and a lack of culturally appropriate treatment options. "We Can Do This" is a web-based app that was designed with input from cultural advisors and end users to support Aboriginal and Torres Strait Islander people seeking to stop or reduce their use of methamphetamine and increase psychosocial well-being.

Objective: This study aimed to evaluate the effectiveness of the "We Can Do This" web-based app as a psychosocial treatment for Aboriginal and Torres Strait Islander people who use methamphetamine.