NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer.

Background: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are remarkably effective for treating EGFR-mutant non-small cell lung cancer (NSCLC). However, patients inevitably develop acquired drug resistance, resulting in recurrence or metastasis. It is important to identify novel effective therapeutic targets to reverse acquired TKI resistance.

The competitive mediating role of basal metabolic rate in the association between polycyclic aromatic hydrocarbon exposure and depression risk.

Background: The effect of basal metabolic rate (BMR) on depression was unclear. This study investigated the potential role of BMR in the association of polycyclic aromatic hydrocarbons (PAHs) exposure and depression.

Methods: The study based on the National Health and Nutrition Examination Survey (NHANES).

Effects of a Hydrophilic Collagen-Reactive Monomer on Dentin Bond Durability.

This study investigated a dilution system comprising a novel hydrophilic aldehyde-based diluent monomer, N-vinyl formamide (NVF), in combination with a hydrophobic aldehyde-based diluent monomer, formyl phenyl acrylate (FA). The binding capability of NVF to dentin collagen was examined by attenuated total reflection-Fourier transform infrared spectroscopy, hydroxyproline release under collagenase degradation, and thermogravimetric analysis. The cytotoxicity of NVF was also evaluated.

Associations between kidney function with all-cause and cause-specific mortality in type 2 diabetes mellitus patients: a prospective cohort study in China.

Background: Abnormal kidney function is associated with adverse outcomes in patients with type 2 diabetes mellitus (T2DM). However, the evidence between kidney function and mortality among Chinese patients with T2DM were still limited.

Methods: This cohort study included 19,919 participants with baseline T2DM from 2013 to 2014 in Jiangsu, China.

Advancing VB Production: Insights into Enhancing VB Titer in Casida A through ARTP Mutagenesis and Multiomics Analysis.

, a microorganism recognized for its capacity to synthesize vitamin B (VB), has garnered significant attention in recent years. Nonetheless, its practical application has been limited by low production yields. Atmospheric and room-temperature plasma (ARTP) mutagenesis was utilized to improve VB production and examine the associated mechanisms.