Publications by authors named "J T Spaeth"

There is growing interest in lifestyle interventions as stand-alone and add-on therapies in mental health care due to their potential benefits for both physical and mental health outcomes. We evaluated lifestyle interventions focusing on physical activity, diet, and sleep in adults with severe mental illness (SMI) and the evidence for their effectiveness. To this end, we conducted a meta-review and searched major electronic databases for articles published prior to 09/2022 and updated our search in 03/2024.

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Background: Interest in passive flow filter systems to remove sevoflurane from anaesthetic machine exhaust have increased recently to mitigate the environmental impact of volatile anaesthetics. These filter systems consist of chemically activated carbon, with limited evidence on their performance characteristics. We hypothesised that their efficiency depends on filter material.

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Article Synopsis
  • The study investigates the roles of BRG1 and BRM ATPase subunits from the SWI/SNF chromatin remodeling complex in the development of endocrine cells, particularly beta cells, which are crucial for insulin production.
  • Researchers created genetically modified mice to analyze the impacts of removing BRG1 in endocrine progenitor cells and varying levels of BRM deficiency, assessing metabolic health and pancreatic islet function.
  • Findings showed that mice with BRG1 and BRM deficiencies faced severe glucose intolerance and reduced insulin secretion due to diminished islet and hormone-producing cell populations, alongside disrupted gene expression crucial for cell differentiation.
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This article reviews the highlights of pertinent literature of interest to the congenital cardiac anesthesiologist published in 2023. After a search of the US National Library of Medicine PubMed database, several topics emerged where significant contributions were made in 2023. The authors of this article considered the following topics noteworthy to be included in this review: (1) advancements in percutaneous mechanical support in children with congenital heart disease, (2) children with pulmonary hypertension undergoing surgery for congenital heart disease, (3) dexmedetomidine in pediatric cardiac surgery, and (4) recommendations for pediatric heart surgery in the United States: Implications for pediatric cardiac anesthesia.

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