Publications by authors named "J T Sertorio"
Introduction: The mechanical obstruction and pulmonary vasoconstriction are major determinants of the sudden right ventricular (RV) afterload increases observed during acute pulmonary thromboembolism (APT). Vasodilators and antioxidants agents have been shown to mitigate pulmonary hypertension. We examined whether sodium nitrite and the antioxidant tempol combination could be advantageous in an APT sheep model.
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- Transfusion of red blood cells (RBCs) that are stored close to their expiration date can cause issues like lower recovery rates and hemolysis, which may impair body functions.
- The study investigates how specific blood from humanized mice with sickle cell trait affects RBC stability and recovery after transfusion in mouse models.
- Findings indicate that RBCs from individuals with sickle cell trait (HbAS) experience quicker breakdown and are cleared faster from the bloodstream due to their inability to maintain flexibility as they age in storage, raising concerns about using these cells when stored for long periods.*