Publications by authors named "J T ROBSON"
Introduction: There is no consensus amongst patients and healthcare professionals about how to measure important adverse effects of glucocorticoids (GCs) that includes the patient's perspective. The OMERACT GC Impact working group sought to identify the domains of greatest importance to both patients and healthcare professionals for use in a proposed core outcome set.
Methods: Patients and healthcare professionals participated in a Delphi consensus exercise to rate the importance of previously identified candidate domains.
Background: Cardiovascular disease has declined but remains a major disease burden across developed countries.
Objective: To assess the effectiveness and cost-effectiveness of statin therapy across United Kingdom population categories.
Design: The cardiovascular disease microsimulation model, developed using Cholesterol Treatment Trialists' Collaboration data and the United Kingdom Biobank cohort, projected cardiovascular events, mortality, quality of life and healthcare costs using participant characteristics.
Article Synopsis
- A mixed methods evaluation was conducted to assess a digital call-and-recall tool aimed at improving the timely receipt and equity of MMR and DTaP/IPV vaccinations in North East London, focusing on children eligible from January 2019 to January 2024.
- The findings showed a 5.3% increase in timely first MMR vaccinations (from 77.7% to 81.8%), while DTaP/IPV saw a smaller increase of 0.9%. However, no significant change in inequality was observed.
- Users found the tool helpful for recall but noted challenges such as staff dynamics and unrealistic national targets that hindered its consistent application; further support is needed to maintain improvements.
Unlabelled: Whooping cough (pertussis) has re-emerged despite high vaccine coverage in Australia and many other countries worldwide, partly attributable to genetic adaptation of the causative organism, to vaccines. Therefore, genomic surveillance has become essential to monitor circulating strains for these genetic changes. However, increasing uptake of PCR for the diagnosis of pertussis has affected the availability of cultured isolates for typing.
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- Ross River virus (RRV) and Barmah Forest virus (BFV) are related viruses found in Australia and Papua New Guinea, showing evidence of convergent evolution in their genetic development.
- Analysis of multiple genomes revealed that specific mutations in key proteins are important for their replication and interaction with host cells, indicating similarities in how both viruses adapt to their environments.
- Although some mutations appear to have benefited their evolution, the overall selection pressures suggest that RRV and BFV have undergone purifying selection, maintaining stable functions during their replication in different hosts like mosquitoes and vertebrates.