Publications by authors named "J T Oever"
Objectives: Previous research has suggested beneficial heterologous effects of the Bacillus Calmette-Guérin (BCG) vaccine on non-mycobacterial infections and other immune-mediated diseases. During the COVID-19 pandemic, randomized controlled trials BCG-PRIME (n = 5349) and BCG-CORONA-ELDERLY (n = 1907) investigated the impact of BCG on SARS-CoV-2 infections in older individuals. We extended the follow-up in these studies by one year (BCG-Long Term study), to assess the overall effects of BCG vaccination on infectious and immune-mediated diseases in individuals aged over 60.
View Article and Find Full Text PDFWhile next generation sequencing has expanded the scientific understanding of Inborn Errors of Immunity (IEI), the clinical use and re-use of exome sequencing is still emerging. We revisited clinical exome data from 1300 IEI patients using an updated in silico IEI gene panel. Variants were classified and curated through expert review.
View Article and Find Full Text PDFOccurrence and predictors of laboratory abnormalities during outpatient parenteral antimicrobial therapy - A multicenter cohort study to inform laboratory test monitoring.
J Infect
November 2024
Objectives: Evidence on the optimal frequency of laboratory testing during outpatient parenteral antimicrobial therapy (OPAT) is lacking. Therefore, we investigated how often and when laboratory abnormalities occur during OPAT and which factors are associated with these abnormalities.
Methods: We performed a multicenter cohort study in four Dutch hospitals among adult patients receiving OPAT and collected routinely obtained laboratory test results.
Article Synopsis
- - Vulvovaginal candidiasis (VVC) impacts up to 75% of women, with roughly 8% experiencing frequent recurrent cases (RVVC), due to host response issues and excessive inflammation.
- - The study examined inflammatory protein levels in 158 RVVC patients and 92 healthy women, using advanced technology to analyze 92 different proteins, without finding significant links to hormonal contraceptive use.
- - RVVC patients showed lower levels of Fibroblast Growth Factor 21 (FGF-21), a potential marker for immune issues related to RVVC, highlighting the possibility of developing new diagnostic tools and treatments.
Objectives: To evaluate the quality of culture follow-up after emergency department (ED) discharge in patients with urinary tract infections (UTIs).
Methods: This convergent mixed methods study included an observational cohort study and a qualitative interview study in UTI patients discharged from the ED of a Dutch university hospital. The primary outcomes of the observational study were the proportion of patients requiring adjustment of antibiotic therapy after culture review, and the proportion of patients in whom these adjustments were made.