Maxillary anterior ridge augmentation with recombinant human bone morphogenetic protein 2.

No human studies exist on the use of recombinant human bone morphogenetic protein 2 (rhBMP-2) on an absorbable collagen sponge (ACS) as a sole graft material for lateral ridge augmentation in large ridge defect sites. This series evaluates the treatment outcome of maxillary anterior lateral ridge augmentation with rhBMP-2/ACS. Twenty patients were treated with rhBMP-2/ACS and fixation screws for space maintenance.

Histologic evaluation of an allogeneic mineralized bone matrix in the treatment of periodontal osseous defects.

The aim of this study was to evaluate the potential of an allogeneic bone matrix to regenerate new bone, cementum, and periodontal ligament around a previously diseased root surface. Four patients with severe chronic periodontitis and teeth with hopeless periodontal or restorative prognoses participated in this study. One tooth with a severe intraosseous defect was selected per patient.

Living cellular construct for increasing the width of keratinized gingiva: results from a randomized, within-patient, controlled trial.

Background: The standard of care for increasing keratinized gingiva adjacent to teeth that do not require root coverage is the free gingival graft (FGG). A pilot study indicated that the use of a living cellular construct (LCC) could be effective in this clinical scenario.

Methods: A pivotal, multicenter, randomized, within-patient, controlled, open-label trial was conducted (N = 96 patients).

Periodontal regeneration using an anabolic peptide with two carriers in baboons.

Background: Various growth proteins have been used to encourage periodontal tissue regeneration. The purpose of this pilot study is to evaluate the periodontal regeneration achieved with the use of a synthetic anabolic peptide (AP) combined with either beta-tricalcium phosphate (beta-TCP) or an absorbable collagen sponge (ACS) as the carrier.

Methods: Periodontal defects were created bilaterally adjacent to four mandibular teeth in five baboons.

Clinical and histologic evaluation of calcium-phosphate bone cement in interproximal osseous defects in humans: a report in four patients.

This study evaluated the clinical and histologic results of a calcium phosphate bone cement in the treatment of human periodontal intraosseous defects. Four patients with chronic advanced periodontitis in whom treatment with complete dentures was planned were recruited. The cement was implanted in one defect per subject with a presurgical probing depth of at least 7 mm and a radiographic bone defect of 4 mm or more.