Publications by authors named "J T Jonker"

Background: Prescribing of psychotropic drugs (PDs) and applying restrictive measures are both frequently used in managing challenging behaviour of people with intellectual disabilities (ID), which is not always according to guidelines or good clinical practice.

Aims: This study aimed to investigate the potential triangular relationship between challenging behaviour, the application of restrictive measures and PD prescription.

Methods And Procedures: In this cross-sectional study, data on challenging behaviour, PD prescription and restrictive measures were collected.

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People with intellectual disabilities (IDs) often present with challenging behaviors (CBs) mostly due to inappropriate environments and mental and physical disorders. Integrative care is recommended to address CBs. However, in clinical practice, psychotropic drugs are often prescribed off-label for CBs, although the effectiveness is unclear, and side effects frequently occur.

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We previously demonstrated that diet supplementation with seaweed () prevented AD-related pathology in a mouse model of Alzheimer's Disease (AD). Here, we tested a lipid extract of seaweed () and a supercritical fluid (SCF) extract of that is free of excess inorganic arsenic. Diet supplementation with extract prevented cognitive deterioration in APPswePS1ΔE9 mice.

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Article Synopsis
  • - A 77-year-old man experienced falls and a humerus fracture due to hypoglycemia, with tests showing low C-peptide and insulin levels, leading to the suspicion of an IGF-2-producing tumor.
  • - Lab tests revealed decreased IGF-1 and increased IGF-2, which was linked to a tumor identified in the right thoracic cavity through imaging.
  • - After surgical removal of the tumor, the patient's hypoglycemic episodes stopped, highlighting the need to consider Nonislet Cell Tumor Hypoglycemia (NICTH) in unexplained cases and the effectiveness of surgery for treatment.
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Torque teno virus (TTV) is emerging as a potential marker for monitoring immune status. In transplant recipients who are immunosuppressed, higher TTV DNA loads are observed than in healthy individuals. TTV load measurement may aid in optimizing immunosuppressive medication dosing in solid organ transplant recipients.

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