Frequent Use of Premenopausal Progestin in Prior Pre-Eclamptic Women.

Context: Women with a history of pre-eclamptic pregnancy are predisposed to later occlusive vascular diseases.

Objective: We compared the use of cyclic progestins or levonorgestrel-releasing intrauterine device (LNG-IUD) for treatment of menstrual cycle abnormalities between premenopausal women with and without a prior pre-eclamptic pregnancy.

Setting And Participants: Register-based cohort study during 1994-2019 of oral progestin or levonorgestrel-releasing intrauterine device (LNG-IUD) in Finnish women with (n=31 688) and without (n=91 726) prior pre-eclampsia in 1969-1993.

Prior pre-eclampsia does not diminish the vascular protective effect of menopausal hormone therapy.

Objective: Women with prior pre-eclampsia are at increased risk of cardiovascular disease (CVD). Menopausal hormone therapy (MHT) may affect this risk. We evaluated the impact of MHT use on cardiovascular risk between women with and without prior pre-eclampsia.

Production and characterization of novel Anti-HIV Fc-fusion proteins in plant-based systems: Nicotiana benthamiana & tobacco BY-2 cell suspension.

Multifunctional anti-HIV Fc-fusion proteins aim to tackle HIV efficiently through multiple modes of action. Although results have been promising, these recombinant proteins are hard to produce. This study explored the production and characterization of anti-HIV Fc-fusion proteins in plant-based systems, specifically Nicotiana benthamiana plants and tobacco BY-2 cell suspension.

Postmenopausal hormone therapy in prior pre-eclamptic women: a nationwide cohort study in Finland.

Objective: We compared the trends of hormone therapy (HT) use among women with and without a history of pre-eclampsia.

Methods: This national cohort study consisted of women with a pre-eclamptic pregnancy ( = 31,688) or a normotensive pregnancy ( = 91,726) (controls) during 1969-1993. The data on their use of HT during 1994-2019 were traced from the National Medicine Reimbursement Register.

Effect of the maternal childbirth experience on a subsequent birth: a retrospective 7-year cohort study of primiparas in Finland.

Objective: To study the effect of the childbirth experience on the likelihood and interval to a subsequent live birth.

Design: Retrospective analysis of a 7-year cohort.

Setting: Childbirths in Helsinki University Hospital delivery units.