Publications by authors named "J T Faragher"
Article Synopsis
- Most ovarian cancer patients develop resistance to chemotherapy within five years, highlighting the need to better understand the tumor microenvironment (TME) and its effect on drug response.
- Researchers created a 3D tumor-on-a-chip model with multiple chambers to mimic the TME and study how it influences drug resistance, using various cell combinations to explore different interactions.
- The study found that the presence of cancer-associated fibroblasts (CAFs) increased drug resistance in ovarian cancer cells, but this could be mitigated using therapies targeting the extracellular matrix, suggesting new avenues for treatment.
Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis.
Arterioscler Thromb Vasc Biol
April 2024
Background: Rheumatic heart disease is the major cause of valvular heart disease in developing nations. Endothelial cells (ECs) are considered crucial contributors to rheumatic heart disease, but greater insight into their roles in disease progression is needed.
Methods: We used a -driven EC lineage-tracing approach to identify and track ECs in the K/B.
Autoimmune Valvular Carditis Requires Endothelial Cell TNFR1 Expression.
Arterioscler Thromb Vasc Biol
June 2023
Background: Inflammation is a key driver of cardiovascular pathology, and many systemic autoimmune/rheumatic diseases are accompanied by increased cardiac risk. In the K/B.g7 mouse model of coexisting systemic autoantibody-mediated arthritis and valvular carditis, valve inflammation depends on macrophage production of TNF (tumor necrosis factor) and IL-6 (interleukin-6).
View Article and Find Full Text PDFSystemic autoantibody-mediated diseases accelerate chronic cardiovascular disease in humans. In the K/B.g7 mouse model of spontaneous autoantibody-mediated inflammatory arthritis, valvular carditis arises in part because of Fc receptor-mediated activation of macrophages, leading to production of pathogenic TNF and IL-6.
View Article and Find Full Text PDFBackground: The current literature suggests that emergency physician (EP)-performed limited compression ultrasound (LCUS) is a rapid and accurate test for deep vein thrombosis (DVT).
Objective: Our primary objective was to determine the sensitivity and specificity of LCUS for the diagnosis of DVT when performed by a large heterogeneous group of EPs.
Methods: This was a prospective diagnostic test assessment of LCUS conducted at two urban academic emergency departments.