Is there an immediate effect on pectoralis minor length after performing a prone scapular retraction exercise using typical sets and repetitions in pain-free participants?

Introduction: Pectoralis Minor (PM) length shortening may contribute to faulty scapular. kinematics and result in shoulder pathology.

Purpose: of the Study: To evaluate if a prone scapular retraction exercise will demonstrate an immediate lengthening of the pectoralis minor (PM) in healthy participants.

Adverse childhood experiences and infidelity: The mediating roles of anxious and avoidant attachment styles.

Infidelity is any behavior that breaks the implied agreement of exclusivity within a romantic relationship and is a leading cause of divorce. Previous literature has established a relationship between Adverse Childhood Experiences (ACEs) and infidelity perpetration. As experiencing childhood adversity does not guarantee an individual will engage in infidelity, mechanisms explaining this relationship should be explored.

Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression.

Background: Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer. The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approaches for patients with high ITH tumors.

Methods: We developed a mouse model of lung adenocarcinoma with defined expression of different neoantigens (NeoAg), enabling us to analyze how these impact antitumor T-cell immunity and to study underlying mechanisms.

Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design.

Limited knowledge exists on the quality of polyclonal antibody responses generated following Marburg virus (MARV) infection and its evolution in survivors. In this study, we evaluate MARV proteome-wide antibody repertoire longitudinally in convalescent phase approximately every six months for five years following MARV infection in ten human survivors. Differential kinetics were observed for IgM vs IgG vs IgA epitope diversity, antibody binding, antibody affinity maturation and Fc-receptor interaction to MARV proteins.