Publications by authors named "J T Colvin"
Article Synopsis
- Protein-based therapeutics face challenges with delivery and site-specific action, but our approach involves covalently attaching these proteins to medical devices for targeted delivery.
- We studied the binding of glucagon-like peptide-2 (GLP-2) to vaginal and intestinal expansion sleeves, using chemically reactive surfaces to enable effective binding of this therapeutic agent.
- Our results showed that about 44% of the applied GLP-2 could be immobilized on the devices, allowing for lower doses to achieve similar therapeutic effects compared to traditional systemic administration, while minimizing side effects.
Article Synopsis
- Sudden unexpected postnatal collapse (SUPC) refers to unexpected deaths in healthy infants aged 6 days or younger, typically in babies born at 34 weeks or later, with a small portion of these cases identified in the years 2010-2020.
- The study found that 1.6% of sudden unexpected infant deaths (SUID) were classified as SUPC, with notable risk factors including surface sharing during sleep, older maternal age, being a first-time mother, and swaddling practices.
- The findings suggest that while SUPC shares some risk factors with SUID at older ages, it also emphasizes the need for clinicians to promote safe sleep guidelines and address risks associated with caregivers falling asleep during feed
Article Synopsis
- Adverse birth outcomes, like preterm births and low birth weight, are linked to socioeconomic disadvantages, with Black infants being disproportionately affected; investing in social programs could help reduce these disparities.* -
- A study analyzed the relationship between state social program funding and rates of preterm birth and low birth weight across the 50 US states from 2011 to 2019.* -
- The findings suggest that higher state expenditures on social programs correlate with lower rates of preterm births overall, especially among infants of Black mothers, highlighting the potential impact of financial support on maternal and infant health.*
Objective: Health literacy is the ability to find, understand, and use information and services to inform health-related decisions and actions. Inadequate health literacy is associated with health disparities, poor health outcomes, and increased emergency department (ED) visits and hospitalizations. Children with medical complexity (CMC) have high rates of acute health care utilization.
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