Identification of Lighting Strike Damage and Prediction of Residual Strength of Carbon Fiber-Reinforced Polymer Laminates Using a Machine Learning Approach.

Due to the complex and uncertain physics of lightning strike on carbon fiber-reinforced polymer (CFRP) laminates, conventional numerical simulation methods for assessing the residual strength of lightning-damaged CFRP laminates are highly time-consuming and far from pretty. To overcome these challenges, this study proposes a new prediction method for the residual strength of CFRP laminates based on machine learning. A diverse dataset is acquired and augmented from photographs of lightning strike damage areas, C-scan images, mechanical performance data, layup details, and lightning current parameters.

Self-Compassion Intervention Programs for Nurses: A Scoping Review.

: Nurses frequently face various sources of stress in the workplace, making self-compassion interventions crucial for promoting their mental well-being. This scoping review aims to: (a) identify self-compassion intervention programs implemented within the nursing population; and (b) analyze the content and outcome measures of these interventions. : The study follows Arksey and O'Malley's scoping review framework and adheres to the PRISMA-ScR guidelines.

Design and Discovery of Preclinical Candidate LYG-409 as a Highly Potent and Selective GSPT1 Molecular Glue Degraders.

Molecular glue degraders induce "undruggable" protein degradation by a proximity-induced effect. Inspired by the clinical success of immunomodulatory drugs, we aimed to design novel molecular glue degraders targeting GSPT1. Here, we report the design of a series of GSPT1 molecular glue degraders.

LINC02418 suppresses endometrial cancer progression via regulating miR-494-3p/RASGRF1 axis.

Long non-coding RNAs (lncRNAs) have emerged as pivotal regulatory molecules in cancer biology. Among these, long intergenic non-protein coding RNA 02418 (LINC02418), a recently identified lncRNA, has been linked to endometrial cancer (EC), although its function and operational mechanisms are largely unclear. The present investigation aims to elucidate the molecular mechanism through which LINC02418 influences EC pathogenesis.

CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium.

Introduction: Cadmium (Cd) and polystyrene microplastics (PS-MPs), two ubiquitous environmental contaminants, produce unique synergistic toxicity when co-existing. Key unanswered questions include specific effects on liver function and potential mechanisms.

Methods: In this study, C57BL/6 mice and AML12 cells were used to establish and models to elucidate the effects of combined exposure to PS-MPs and Cd on the liver and their mechanisms.