Publications by authors named "J Szarek"
Health disparities exist among groups that are based on race, ethnicity, gender, socioeconomic status, and geography. Often, interventions directed at addressing these disparities are episodically incorporated into health professions education as opposed to a more uniform integration throughout a curriculum. Thus, a working framework for integrating and assessing diversity, equity, and inclusion (DEI) specifically into foundational science teaching in health professions' education is needed.
View Article and Find Full Text PDFGenotoxicity in the absence of inflammation after tungsten inhalation in mice.
Environ Toxicol Pharmacol
March 2023
Tungsten is used in several applications and human exposure may occur. To assess its pulmonary toxicity, we exposed male mice to nose-only inhalation of tungsten particles at 9, 23 or 132 mg/m (Low, Mid and High exposure) (45 min/day, 5 days/week for 2 weeks). Increased genotoxicity (assessed by comet assay) was seen in bronchoalveolar (BAL) fluid cells at Low and High exposure.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effects of various metal oxide nanomaterials, like ZnO and CuO, on the acute phase response (APR) in mice, which relates to inflammation and cardiovascular disease risk.
- After exposure to these nanomaterials, researchers found increased levels of inflammatory markers (like Saa3 and SAA1) in the lungs and liver, as well as elevated neutrophil counts and enzyme activity in lung fluid.
- Findings indicate that both soluble and insoluble metal oxides trigger a dose-dependent APR, with specific biological markers suggesting their potential use for assessing cardiovascular disease risk following particle exposure.
Molybdenum disulphide (MoS) is a constituent of many products. To protect humans, it is important to know at what air concentrations it becomes toxic. For this, we tested MoS particles by nose-only inhalation in mice.
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