Publications by authors named "J Szaleniec"
Article Synopsis
- 15-oxo-eicosatetraenoic acid (15-oxo-ETE) is linked to arachidonic acid metabolism and was found to be overproduced in patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD).
- A study involving patients with N-ERD, asthmatics who tolerate aspirin, and healthy controls measured levels of 15-oxo-ETE and leukotriene E (LTE) to evaluate their potential as diagnostic markers.
- Results showed that 15-oxo-ETE levels were significantly higher in N-ERD patients, leading to the development of the Aspirin Hypersensitivity Diagnostic Index (AHDI) which showed strong accuracy in
<b><br>Introduction:</b> Rhinomanometry is an otolaryngological diagnostic method used to determine airflow as a function of the pressure drop through the left and right nasal cavities. Airflow is measured using orifice flowmeters that attenuate the flow.</br> <b><br>Aim:</b> This paper describes the results of a study into the effects of flowmeter design on rhinomanometry results and detection of nasal airflow asymmetry.
View Article and Find Full Text PDFBackground: The sinus microbiome in patients with chronic rhinosinusitis (CRS) is considered homogenous across the sinonasal cavity. The middle nasal meatus is the recommended sampling site for 16S rRNA sequencing. However, individuals with unusually high between-site variability between the middle meatus and the sinuses were identified in previous studies.
View Article and Find Full Text PDFBackground: The cellular inflammatory pattern of nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is heterogeneous. However, data on the heterogeneity of non-eosinophilic asthma (NEA) with aspirin hypersensitivity are scanty. By examination of N-ERD patients based on clinical data and eicosanoid biomarkers we aimed to identify NEA endotypes potentially guiding clinical management.
View Article and Find Full Text PDFAim: The aim of the study was to compare the flow disturbances in computational fluid dynamics (CFD) technique based on computed tomography (CT) to the results of active anterior rhinomanometry (RMM), in patients with nasal septum deviation (NSD).
Material And Methods: In 24 patients with NSD, RMM and CT of the paranasal sinuses were performed as a part of typical clinical management. For each patient, 3D models of air-filled spaces in the nasal cavity were created, based on CT images, and air flow simulations during inhalation were performed using CFD technique.