Publications by authors named "J Szaflarski"
Traumatic brain injury (TBI) and subsequent post-traumatic epilepsy (PTE) often impair daily activities and mental health (MH), which contribute to long-term TBI-related disability. PTE also affects driving capacity, which impacts functional independence, community participation, and satisfaction with life (SWL). However, studies evaluating the collective impact of PTE on multidimensional outcomes are lacking.
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- Researchers developed prediction models to estimate the risk of posttraumatic epilepsy (PTE) in individuals who experienced moderate-to-severe traumatic brain injuries (TBI) during a two-year recovery period.
- The study utilized data from over 6,000 participants in the TBI Model Systems National Database, performing analyses to create models that account for various factors influencing seizure risk post-injury.
- Key findings indicated that Model 3, which focused on predicting new or recurrent seizures in the second year, had the highest sensitivity (86.63%) and effectiveness, with factors like cranial surgeries and traumatic hemorrhages being significant risk predictors across all models.
Objective: Epileptogenesis is linked to neuroinflammation. We hypothesized that local heat production caused by neuroinflammation can be visualized non-invasively in vivo via brain magnetic resonance spectroscopic imaging (MRSI) and MRSI-thermometry (MRSI-t) and that there is a relationship in patients with temporal lobe epilepsy (TLE) between MRSI-t and brain metabolites choline and myo-inositol and between neuroimaging and cellular and serum biomarkers of inflammation.
Methods: Thirty-six (36) participants, 18 with temporal lobe epilepsy (13 females) and 18 age-matched healthy controls (nine females), were enrolled prospectively and underwent MRSI/MRSI-t; TLE participants also provided blood samples.
Article Synopsis
- The study investigates the effectiveness of neurobehavioral therapy (NBT) on adults with traumatic brain injury (TBI) who either experience functional seizures (FS) or epilepsy, comparing their outcomes to those without seizures over one year. !* -
- A total of 193 participants were divided into three groups: TBI+FS (89), TBI+epilepsy (29), and TBI without seizures (75), with the first two groups receiving NBT, while the last received standard care. !* -
- Results showed significant reductions in seizure frequency for TBI+FS participants during treatment, while TBI+epilepsy also experienced some decrease, though not statistically significant; secondary outcomes assessed included mental
Connectome-based lesion-symptom mapping relates behavioural impairments to disruption of structural brain connectivity. Connectome-based lesion-symptom mapping can be based on different approaches (diffusion MRI versus lesion mask), network scales (whole brain versus regions of interest) and measure types (tract-based, parcel-based, or network-based metrics). We evaluated the similarity of different connectome-based lesion-symptom mapping processing choices and identified factors that influence the results using multiverse analysis-the strategy of conducting and displaying the results of all reasonable processing choices.
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