Publications by authors named "J Szade"
Article Synopsis
- Micronuclei (MN) are formed through various mechanisms, and their frequent presence in tumors suggests they might actively contribute to cancer progression rather than being just passive byproducts.
- This study highlights how damages during cell division can lead to the accumulation of Emerin in MN, which lack Lamin A/C and feature the Lamin-B receptor and Sec61β.
- Emerin mislocalization to MN is linked to a poor prognosis in prostate cancer patients and is associated with increased migratory and invasive behaviors of tumor cells, particularly in environments rich in collagen.
Macrophage activation syndrome is a severe and potentially fatal condition in rheumatology. It can involve many different organs and systems, including the cardiovascular system, but heart failure due to its course is a relatively rare occurrence. In the following paper, we present a case of a young woman with newly diagnosed systemic lupus erythematosus who, in the span of two months, developed macrophage activation syndrome and acute heart failure, which caused her death.
View Article and Find Full Text PDFBackground: Cancer-associated fibroblasts (CAFs) have been shown to support tumor development in a variety of cancers. Different markers were applied to classify CAFs in order to elucidate their impact on tumor progression. However, the exact mechanism by which CAFs enhance cancer development and metastasis is yet unknown.
View Article and Find Full Text PDFBackground: Cancer-associated fibroblasts (CAFs) are the most abundant cell type in the tumor microenvironment (TME). Estrogen receptor alpha 36 (ERα36), the alternatively spliced variant of ERα, is described as an unfavorable factor when expressed in cancer cells. ERα can be expressed also in CAFs; however, the role of ERα36 in CAFs is unknown.
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