Publications by authors named "J Swinnen"
Cancer cells in acidic tumor regions are aggressive and a key therapeutic target, but distinguishing between acid-exposed and hypoxic cells is challenging. Here, we use carbonic anhydrase 9 (CA9) antibodies to mark acidic areas in both hypoxic and respiring tumor areas, along with an HRE-GFP reporter for hypoxia, to isolate distinct cell populations from 3D tumor spheroids. Transcriptomic analysis of CA9-positive, hypoxia-negative cells highlights enriched fatty acid desaturase activity.
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- Prostate cancer treatment resistance is a major challenge, with genomic studies revealing how cancer cells evade therapies, yet the tumor microenvironment's (TME) role remains unclear.
- A study using advanced techniques on samples from 120 patients offers a detailed transcriptomic profile of the prostate TME throughout the treatment process.
- The research highlights a unique cell type called club-like cells that interact with the immune system, suggesting their involvement in inflammation and resistance to androgen deprivation therapy, indicating they could be potential targets for new treatments.
Background: During Alzheimer's disease (AD) progression, there is a decline in the bioactive sphingolipid sphingosine-1-phosphate (S1P). Previous research showed that FTY720, an S1P mimetic, prevented cognitive decline and reduced ceramide levels in transgenic mice with familial AD carrying the human APOE4 gene (E4FAD) at 6-7 months of age.
Objective: The objective of this study is to explore the protective effects of FTY720 at late-stage AD.
Article Synopsis
- Transitioning from a proliferative to an invasive melanoma phenotype increases vulnerability to ferroptosis, but the regulatory circuits behind this susceptibility are unclear.
- Apolipoprotein E (ApoE) was identified as a key lipid-metabolism gene that helps differentiate between ferroptosis-resistant and sensitive melanoma states by protecting invasive cells from ferroptosis-inducing agents.
- The study suggests that ApoE secretion and its expression may serve as potential biomarkers for poor response to ferroptosis in melanoma patients.