Racial Disparity in Obstructive Sleep Apnea Care and its Impact on Cardiovascular Health.

Purpose Of Review: Racial disparities in sleep health as well as the diagnosis and treatment of sleep disorders have emerged as a key driver of cardiovascular outcomes. Obstructive sleep apnea (OSA), is characterized by repeated airway obstructions during sleep and is associated with an increased risk of cardiovascular disease. While racial and ethnic minorities have disproportionately high OSA prevalence rates, diagnosis rates remain low.

Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation.

The appearance of misfolded and aggregated proteins is a pathological hallmark of numerous neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Sleep disruption is proposed to contribute to these pathological processes and is a common early feature among neurodegenerative disorders. Synucleinopathies are a subclass of neurodegenerative conditions defined by the presence of α-synuclein aggregates, which may not only enhance cell death, but also contribute to disease progression by seeding the formation of additional aggregates in neighboring cells.

[Malignant lymphoma of both testes].

A patient with rare primary lymphoma of the testis is presented. Several investigators have reported the prognosis in the majority of patients was associated with a poor outcome. In our case poor prognostic factors and the presence of many symptoms, such as fever, night sweets or weight loss significant influenced on the prognosis and the length of disease free-survival in patient with testicular lymphoma.

[Bone metastasis in patients with urogenital neoplasms].

The clinical data of 91 patients with bone metastases were reviewed. The renal cell carcinoma and prostatic carcinoma were diagnosed respectively in 53% and 47% of the patients. 48% of the patients had tumour size stage T3 and 71% had histopathological stage II (G2).

[Primary non-Hodgkin's lymphoma of the prostate].

A patient with a rare primary lymphoma of the prostate is presented. Clinical symptoms may be a reason of mistake, that are highly suggestive of benign prostatic hyperplasia or prostatic adenocarcinoma. Before treatment all patients should have to determined the histopathological diagnosis (made by prostatic biopsy or by prostatectomy) because treatment of patients with primary non-Hodgkin's lymphoma of the prostate is quite different then treatment of patients with prostatic adenocarcinoma.