Publications by authors named "J Swales"
With increased use of mass spectrometry imaging (MSI) in support of pharmaceutical research and development, there are opportunities to develop analytical pipelines that incorporate exploratory high-performance analysis with higher capacity and faster targeted MSI. Therefore, to enable faster MSI data acquisition we present analyte-targeted desorption electrospray ionization-mass spectrometry imaging (DESI-MSI) utilizing a triple-quadrupole (TQ) mass analyzer. The evaluated platform configuration provided superior sensitivity compared to a conventional time-of-flight (TOF) mass analyzer and thus holds the potential to generate data applicable to pharmaceutical research and development.
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- - This study explores the effects of tissue fixation using formalin and paraffin on metabolomics and drug distribution analysis, particularly in the context of mass spectrometry imaging techniques.
- - Findings reveal that formalin fixation leads to significant loss of polar molecules and alters lipid structures, affecting tissue analysis outcomes, particularly in terms of metabolite profiles.
- - The process of fixation is shown to have time-dependent impacts, with slower fixation associated with increased lipid degradation and changes in metabolite distribution, which complicate histological evaluations.
The authors wish to make the following corrections to this paper [1][...
View Article and Find Full Text PDFBackground The COVID-19 pandemic continues to devastate communities all over the world. The aim of this study was to evaluate the efficacy and safety of the test agent as a prophylaxis against SARS-CoV-2 infection in a population of high-risk healthcare workers. Methods The study was a multi-centre, prospective, double blind, randomized, placebo-controlled trial.
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