The Importance of Subcellular Structures to the Modeling of Biological Cells in the Context of Computational Bioelectromagnetics Simulations.

Numerical investigation of the interaction of electromagnetic fields with eukaryotic cells requires specifically adapted computer models. Virtual microdosimetry, used to investigate exposure, requires volumetric cell models, which are numerically challenging. For this reason, a method is presented here to determine the current and volumetric loss densities occurring in single cells and their distinct compartments in a spatially accurate manner as a first step toward multicellular models within the microstructure of tissue layers.

Particle Size-Dependent Onset of the Tunneling Regime in Ideal Dimers of Gold Nanospheres.

We report on the nanoparticle-size-dependent onset of quantum tunneling of electrons across the subnanometer gaps in three different sizes (30, 50, and 80 nm) of highly uniform gold nanosphere (AuNS) dimers. For precision plasmonics, the gap distance is systematically controlled at the level of single C-C bonds via a series of alkanedithiol linkers (C-C). Parallax-corrected high-resolution transmission electron microscope (HRTEM) imaging and subsequent tomographic reconstruction are employed to resolve the nm to subnm interparticle gap distances in AuNS dimers.

A self-matched leaky-wave antenna for ultrahigh-field magnetic resonance imaging with low specific absorption rate.

The technology of magnetic resonance imaging is developing towards higher magnetic fields to improve resolution and contrast. However, whole-body imaging at 7 T or even higher flux densities remains challenging due to wave interference, tissue inhomogeneities, and high RF power deposition. Nowadays, proper RF excitation of a human body in prostate and cardiac MRI is only possible to achieve by using phased arrays of antennas attached to the body (so-called surface coils).

Probing the SERS brightness of individual Au nanoparticles, hollow Au/Ag nanoshells, Au nanostars and Au core/Au satellite particles: single-particle experiments and computer simulations.

Different classes of plasmonic nanoparticles functionalized with the non-resonant Raman reporter molecule 4-MBA are tested for their SERS signal brightness at the single-particle level: gold nanoparticles, hollow gold/silver nanoshells, gold nanostars, and gold core/gold satellite particles. Correlative SERS/SEM experiments on a set of particles from each class enable the unambiguous identification of single particles by electron microscopy as well as the characterization of both their elastic (LSPR) and inelastic (SERS) scattering spectra. Experimental observations are compared with predictions from FEM computer simulations based on 3D models derived from representative TEM/SEM images.

[Serious manifestation of primary hypothyroidism].

Thyroid gland diseases are the most frequent endocrinopathy and can be often seen in adult population. They occur at least by 5% of the population and the occurence increases with age, in females aging 45 and more, as thyroid gland diseases in this age group are represented approximately by 20%. Due to a complex influence of thyroid hormones in humans, diagnosis of thyroid disease may remain unsuspected under other disease with typical symptoms; the most serious of them is cardiogenic manifestation.