Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice.

Leukemia relapse is a major cause of death after allogeneic hematopoietic cell transplantation (allo-HCT). We tested the potential of targeting T cell (Tc) immunoglobulin and mucin-containing molecule 3 (TIM-3) for improving graft-versus-leukemia (GVL) effects. We observed differential expression of TIM-3 ligands when hematopoietic stem cells overexpressed certain oncogenic-driver mutations.

The 24-hour interval compression plan: part 2-lifestyle and therapeutic regimens to manage chronic oedema case series.

Objective: The aim of this case series was to retrospectively assess the impact on volume control and patients' quality of life (QOL) when a night-time garment was added to their previous compression regimen for a full 24-hour interval compression plan.

Method: Patients who had a history of chronic oedema presented to one of two oedema management centres in the US for treatment for oedema exacerbation and/or suboptimal performance of their current garments. Objective data examined were circumferential limb volume (cm) measurements and QOL measured with the Lymphoedema QOL Tool (LYMQOL-Leg and LYMQOL-Arm).

Acromioclavicular Joint Injuries in Professional Ice Hockey Players: Epidemiologic and MRI Findings and Association With Return to Play.

Background: Acromioclavicular joint (ACJ) injuries are common in ice hockey players and are traditionally evaluated with conventional radiography, which has recognized limitations in the accurate characterization of the spectrum of soft tissue injuries and severity/grade of injury sustained.

Purpose: To evaluate the epidemiologic, clinical, and magnetic resonance imaging (MRI) findings in professional ice hockey players who have sustained acute ACJ injuries.

Study Design: Case series; Level of evidence, 4.

Spontaneous rupture of a rare adrenal artery aneurysm mimicking a ruptured abdominal aortic aneurysm.

Spontaneous adrenal artery aneurysm rupture is an exceedingly rare but life-threatening condition that requires emergent treatment. We report on an 80-year-old male who underwent an emergent exploratory laparotomy and repair of a ruptured adrenal artery aneurysm and highlight the role of both vascular surgery and interventional radiology in the management of this scenario.

Translating an evidence-based protocol for nurse-to-nurse shift handoffs.

Purpose: Ineffective communication is the most frequently reported cause of sentinel events in U.S. hospitals.