Publications by authors named "J Sulkowska"
Cardiac troponin T associates with left ventricular function and synchrony assessed by CMR in the general population: results from the Akershus Cardiac Examination 1950 Study.
Eur Heart J Imaging Methods Pract
July 2024
Background And Aim: Cardiac troponin T (cTnT) is a blood biomarker of myocardial injury that is associated with future adverse cardiovascular events in the general population. Left ventricular (LV) global longitudinal strain (GLS) and mechanical dispersion (MD) are metrics of systolic function and synchrony that can be obtained from cardiac imaging. Studies suggest an association between cTnT and echocardiographically assessed GLS and MD, but it is unknown whether cTnT relates to these metrics when assessed by cardiac magnetic resonance (CMR).
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- The study aimed to identify microRNAs (miRNAs) that may influence SMAD protein activity in different subtypes of breast cancer in Polish women, analyzing five subtypes: luminal A, luminal B HER2-, luminal B HER2+, non-luminal HER2+, and TNBC.
- Using various molecular analysis techniques, the researchers found overexpression of SMAD3 and SMAD5 in all breast cancer types, potentially linked to reduced levels of miR-145, while SMAD7 was underexpressed, possibly due to lower activity of miR-15b and miR-21b.
- Overall, the findings suggest that excessive SMAD protein activation may lead to tumor growth
We study and characterize the topology of connectivity circuits observed in natively folded protein structures whose coordinates are deposited in the Protein Data Bank (PDB). Polypeptide chains of some proteins naturally fold into unique knotted configurations. Another kind of nontrivial topology of polypeptide chains is observed when, in addition to covalent bonds connecting consecutive amino acids in polypeptide chains, one also considers disulfide and ionic bonds between non-consecutive amino acids.
View Article and Find Full Text PDFRecent advances in Machine Learning methods in structural biology opened up new perspectives for protein analysis. Utilizing these methods allows us to go beyond the limitations of empirical research, and take advantage of the vast amount of generated data. We use a complete set of potentially knotted protein models identified in all high-quality predictions from the AlphaFold Database to search for any common trends that describe them.
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- Researchers have identified the most complex knotted proteins, specifically double trefoil knots (3 3), after 30 years of studying knotted proteins.
- They discovered five different domain arrangements that yield double-knotted structures in nearly a thousand proteins, particularly in membrane proteins and carbonic anhydrases.
- The study employed AlphaFold and RoseTTaFold for predicting double knot presence and demonstrated that the TrmD-Tm1570 protein from the SPOUT superfamily successfully folds and functions in modifying tRNA, although questions remain about its folding and degradation processes.