Publications by authors named "J Subash Chandra"
Article Synopsis
- - Therapeutic DNA cancer vaccines stimulate immune responses but often fall short in effectiveness; researchers found that manganese-doped silica nanoparticles (MSNA) can enhance these vaccines' performance.
- - When combined with plasmid DNA encoding cancer antigens like α-fetoprotein, MSNA significantly increased specific immune responses in animal models, leading to better cancer immunity.
- - The study showed that MSNA not only improved T cell responses against cancer but also successfully prevented tumor growth in models for both liver and HPV-related cancers.
Objectives: Langerhans cells (LCs) are epithelial antigen-presenting cells (APC) contributing to immune surveillance. LCs depend on interleukin 34 (IL34) production by epithelial cells. This study aimed to uncover mechanisms of alteration of IL34 and LC function in squamous cell carcinoma (SCC).
View Article and Find Full Text PDFBackground: This study assessed whether deep learning applied to routine outpatient chest X-rays (CXRs) can identify individuals at high risk for incident chronic obstructive pulmonary disease (COPD).
Methods: Using cancer screening trial data, we previously developed a convolutional neural network (CXR-Lung-Risk) to predict lung-related mortality from a CXR image. In this study, we externally validated CXR-Lung-Risk to predict incident COPD from routine CXRs.
Article Synopsis
- The treatment of cancer has become more complex, utilizing traditional methods like chemotherapy and surgery, but innovative approaches are emerging, particularly involving folic acid-conjugated metal-based nanoparticles (NP) for targeted therapies, specifically photodynamic therapy (PDT) and photothermal therapy (PTT).
- These nanoparticles leverage the affinity of folic acid for folate receptors, which many cancer cells produce in excess, allowing for more precise and effective treatment delivery.
- The review highlights how these FA-functionalized metal nanoparticles enhance the effectiveness of PDT and PTT in lab and animal models, while also addressing challenges and future directions for their clinical application.
Background & Aims: In Crohn's disease, wrapping of mesenteric fat around the bowel wall, so-called "creeping fat," is highly associated with strictures. The strongest contributor to luminal narrowing in strictures is a thickening of the human intestinal muscularis propria (MP). We investigated creeping fat-derived factors and their effect on mechanisms of human intestinal MP smooth muscle cell (HIMC) hyperplasia.
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