Publications by authors named "J Stubert"
Article Synopsis
- Pathogenic heterozygous mutations in the GRN gene are a significant cause of frontotemporal dementia (FTD), leading to lower levels of the progranulin protein in biofluids, which has sparked therapeutic trials aimed at increasing these levels.
- A systematic review of literature on biofluid PGRN concentrations included data from 7071 individuals, primarily focusing on plasma PGRN levels derived from a single assay type, which accounted for variations based on mutation type, age, sex, and clinical diagnosis.
- Key findings established specific concentration cut-offs for plasma (74.8 ng/mL) and CSF (3.43 ng/mL) and indicated that plasma PGRN levels vary by mutation type,
[This corrects the article DOI: 10.1055/a-2196-6224.].
View Article and Find Full Text PDFIn recent years, the concept of quality of life (QoL) has gained significant importance within health care and clinical research, e.g., as in patient-reported outcomes.
View Article and Find Full Text PDFArticle Synopsis
- Pregnant women with COVID-19 face higher risks of severe complications, especially those with multiple pregnancies due to physical changes in lung function caused by the growing fetus.
- A study analyzed outcomes in 5514 women with symptomatic COVID-19 during pregnancy, focusing on the difference between those with multiple pregnancies and those with singletons.
- Results showed that while the overall incidence of adverse outcomes was similar, multiple pregnancies had earlier onset of complications and certain factors like high preconceptional BMI significantly increased risks.