Publications by authors named "J Strojil"
Article Synopsis
- This study compares parametric and nonparametric population pharmacokinetic modeling of the antibiotic imipenem in critically ill patients to enhance dosing effectiveness.* -
- While both modeling approaches showed adequate predictive performance for patients with eGFRs (estimated Glomerular Filtration Rate) ≥ 78 mL/min, they were less reliable for patients with lower eGFRs.* -
- Simulations revealed that while 50% of the Probability of Target Attainment (PTA) results were similar between models, differences arose due to higher variability in the nonparametric model, highlighting the need for further investigation on clinical implications.*
Aims: Pharmacotherapy in geriatric patients is challenging due to frequent multimorbidity, polypharmacy, increased risk of adverse drug effects, and altered pharmacokinetics and pharmacodynamics associated with aging. Therapeutic drug monitoring (TDM) is a dosing individualisation strategy that helps to minimise toxicity whilst maximising the efficacy of the agent. Routine TDM of vancomycin is recommended in clinical practice in order to optimise drug exposure.
View Article and Find Full Text PDFSeroprevalence studies represent a very important tool to find out what fraction of population has already met with the new type of coronavirus (e.g. SARS-CoV-2).
View Article and Find Full Text PDF1. The underlying microbial metabolic activity toward xenobiotics is among the least explored factors contributing to the inter-individual variability in drug response. 2.
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