Effect of Aprepitant on Etoposide Pharmacokinetics in Patients with Testicular Cancer: A Pharmacokinetic Study to Determine the Absence of a Clinically Relevant Interaction.

All patients treated with anticancer agents should receive the most effective anti-emetic regimen. Anti-emetic guidelines provide recommendations but do not take into account possible drug-drug interactions between anti-emetics and anticancer drugs. This study determines the clinical relevance of the potential drug-drug interaction of the neurokinin-1 receptor antagonist, aprepitant, on the pharmacokinetics of etoposide.

The relationship between the use of Touch Screen Devices and interference suppression in children aged 5-11.

Objective: To investigate the relation between the use of Touch Screen Devices (TSDs), such as smartphones and tablets, and interference suppression as assessed by the Bivalent Shape Task (BST) in 5-11-year-old children.

Methods: Thirty-eight children from a Dutch primary school were included. Interference suppression was measured in the incongruent level of the BST.