Effects of intratympanic injection of latanoprost in Meniere's disease: a randomized, placebo-controlled, double-blind, pilot study.

Objective: To determine the short-term effects of latanoprost, a selective FP prostanoid receptor agonist, in Meniere's disease.

Study Design And Methods: Latanoprost was administered by intratympanic injection once daily for 3 days. Before the first injection (day 1) and on days 5 and 15, hearing and tinnitus were determined.

Detection of the free acid of bimatoprost in aqueous humor samples from human eyes treated with bimatoprost before cataract surgery.

Purpose: To determine whether bimatoprost is hydrolyzed to its free acid after topical application in humans in vivo.

Design: Prospective, masked, and vehicle controlled.

Participants: Thirty-one eyes of 31 patients with cataracts.

Localization of prostanoid receptors and cyclo-oxygenase enzymes in guinea pig and human cochlea.

Endogenous production of prostaglandins has been demonstrated in the cochlea, but no information is available on the distribution of the cyclo-oxygenase (COX) enzymes, or prostanoid receptors in the cochlea. The purpose of the present study was to investigate the localization of the FP, EP(1) and EP(3) prostanoid receptors as well as the COX-1 and COX-2 enzymes in the cochlea of guinea pig and man. Cochleas were processed for immunohistochemistry using routine techniques.

Studies on ocular inflammation and development of a prostaglandin analogue for glaucoma treatment.

This review summarizes the Ernst H. Bárány Prize Lecture given at the meeting of the International Society of Eye Research in Geneva 2002. In the paper the path from the author's early studies on neurogenic inflammation in the eye to the search for a suitable prostaglandin analogue for glaucoma treatment, and the development of latanoprost are described.