Publications by authors named "J Stith"
Sphingosine kinase 1 (SK1) is a key sphingolipid enzyme that is upregulated in several types of cancer, including lymphoma which is a heterogenous group of malignancies. Treatment for lymphoma has improved significantly by the introduction of new therapies; however, subtypes with tumor protein P53 (p53) mutations or deletion have poor prognosis, making it critical to explore new therapeutic strategies in this context. SK1 has been proposed as a therapeutic target in different types of cancer; however, the effect of targeting SK1 in cancers with p53 deletion has not been evaluated yet.
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- Senescence is a natural process that stops cells from growing, which helps prevent tumors; certain genes like K-Ras can cause this process in cells.* -
- In a study with specific cells, scientists found that K-Ras increases certain chemicals called ceramides and affects a protein called sphingosine kinase 1 (SK1), which plays a role in cell growth.* -
- By lowering levels of SK1, the scientists were able to increase signs of senescence and stop cell growth, suggesting that targeting SK1 could be a new way to treat cancer.*
Objectives/hypothesis: The purpose of this study is to develop consensus on key points that would support the use of systemic bevacizumab for the treatment of recurrent respiratory papillomatosis (RRP), and to provide preliminary guidance surrounding the use of this treatment modality.
Study Design: Delphi method-based survey series.
Methods: A multidisciplinary, multi-institutional panel of physicians with experience using systemic bevacizumab for the treatment of RRP was established.
Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2.
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